Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats.

@article{Sakai2004HemoglobinvesiclesSI,
  title={Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats.},
  author={Hiromi Sakai and Yoshiyasu Masada and Hirohisa Horinouchi and Manabu Yamamoto and Eiji Ikeda and Shinji Takeoka and Koichi Kobayashi and Eishun Tsuchida},
  journal={Critical care medicine},
  year={2004},
  volume={32 2},
  pages={
          539-45
        }
}
OBJECTIVE Hemoglobin-vesicle (HbV) has been developed to provide oxygen-carrying ability to plasma expanders. Its ability to restore the systemic condition after hemorrhagic shock was evaluated in anesthetized Wistar rats for 6 hrs after resuscitation. The HbV was suspended in 5 g/dL recombinant human serum albumin (HbV/rHSA) at an Hb concentration of 8.6 g/dL. DESIGN Prospective, randomized, controlled trial. SETTING Department of Surgery, School of Medicine, Keio University. SUBJECTS… CONTINUE READING
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