Hemoglobin-vesicles as oxygen carriers: influence on phagocytic activity and histopathological changes in reticuloendothelial system.

@article{Sakai2001HemoglobinvesiclesAO,
  title={Hemoglobin-vesicles as oxygen carriers: influence on phagocytic activity and histopathological changes in reticuloendothelial system.},
  author={Hiromi Sakai and Hirohisa Horinouchi and Katsunori Tomiyama and Eiji Ikeda and Shinji Takeoka and Koichi Kobayashi and Eishun Tsuchida},
  journal={The American journal of pathology},
  year={2001},
  volume={159 3},
  pages={1079-88}
}
Hemoglobin-vesicles (HbV) have been developed for use as artificial oxygen carriers (particle diameter, 250 nm) in which a purified Hb solution is encapsulated with a phospholipid bilayer membrane. The influence of HbV on the reticuloendothelial system was studied by carbon clearance measurements and histopathological examination. The HbV suspension ([Hb] = 10 g/dl) was intravenously infused in male Wistar rats at dose rates of 10 and 20 ml/kg, and the phagocytic activity was measured by… CONTINUE READING

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