Hemoglobin synthesis in beta-thalassemia: the properties of the free alpha-chains.

  • Arthur Bank
  • Published 1968 in The Journal of clinical investigation


The decrease in hemoglobin A (HbA, alpha(2)beta(2)) synthesis in the erythroid cells of patients with beta-thalassemia is due to a selective defect in beta-chain synthesis. Since alpha-chains continue to be formed at a normal rate in these cells, this results in a marked relative excess of alpha-chain synthesis over beta- and gamma-chain synthesis. The… (More)


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