Hemoglobin metabolism in the malaria parasite Plasmodium falciparum.

@article{Francis1997HemoglobinMI,
  title={Hemoglobin metabolism in the malaria parasite Plasmodium falciparum.},
  author={S. Francis and D. Sullivan and D. Goldberg},
  journal={Annual review of microbiology},
  year={1997},
  volume={51},
  pages={
          97-123
        }
}
Hemoglobin degradation in intraerythrocytic malaria parasites is a vast process that occurs in an acidic digestive vacuole. Proteases that participate in this catabolic pathway have been defined. Studies of protease biosynthesis have revealed unusual targeting and activation mechanisms. Oxygen radicals and heme are released during proteolysis and must be detoxified by dismutation and polymerization, respectively. The quinoline antimalarials appear to act by preventing sequestration of this… Expand
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