Hemoglobin-mediated selenium export from red blood cells

@article{Haratake2007HemoglobinmediatedSE,
  title={Hemoglobin-mediated selenium export from red blood cells},
  author={Mamoru Haratake and Katsuyoshi Fujimoto and Ritsuko Hirakawa and Masahiro Ono and Masahito Nakayama},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2007},
  volume={13},
  pages={471-479}
}
On the basis of the fact that selenium from selenite binds to hemoglobin (Hb), we investigated the missing process in the selenium export from red blood cells (RBCs), i.e., the transfer of selenium bound to Hb to RBC membrane proteins. To elucidate the molecular events of the Hb-associated selenium export from RBC, a Hb–Se complex was synthesized from thiol-exchange of Cys-β93 in Hb with penicillamine-substituted glutathione selenotrisulfide, as a model of major metabolic intermediates, and… CONTINUE READING
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