Hemoglobin interaction with GP1bα induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis.

@article{Singhal2015HemoglobinIW,
  title={Hemoglobin interaction with GP1bα induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis.},
  author={Rashi Singhal and Gowtham Kumar Annarapu and Ankita Pandey and Sheetal Chawla and Amrita Ojha and Avinash Gupta and M M Araujo Cruz and Tulika Seth and Prasenjit Guchhait},
  journal={Haematologica},
  year={2015},
  volume={100 12},
  pages={1526-33}
}
Intravascular hemolysis increases the risk of hypercoagulation and thrombosis in hemolytic disorders. Our study shows a novel mechanism by which extracellular hemoglobin directly affects platelet activation. The binding of Hb to glycoprotein1bα activates platelets. Lower concentrations of Hb (0.37-3 μM) significantly increase the phosphorylation of… CONTINUE READING