Hemoglobin genotype, fertility, and the malaria hypothesis.


Epidemiological and clinical studies (Fleming et al. 1985; Perrin et al. 1982) indicate that hemoglobin (Hb) AS individuals have a selective advantage in malarial environments. Thus the high frequency of Hb S in human populations has been attributed to the decreased malarial morbidity and mortality experienced by Hb AS heterozygotes. It has also been… (More)


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@article{Madrigal1989HemoglobinGF, title={Hemoglobin genotype, fertility, and the malaria hypothesis.}, author={Lorena Madrigal}, journal={Human biology}, year={1989}, volume={61 3}, pages={311-25} }