Hemoglobin e syndromes.

@article{Vichinsky2007HemoglobinES,
  title={Hemoglobin e syndromes.},
  author={Elliott Vichinsky},
  journal={Hematology. American Society of Hematology. Education Program},
  year={2007},
  pages={
          79-83
        }
}
  • E. Vichinsky
  • Published 2007
  • Medicine
  • Hematology. American Society of Hematology. Education Program
Hemoglobin (Hb) E is one of the world's most common and important mutations. It results in a heterogeneous group of disorders whose phenotype range from asymptomatic to severe. Hb E trait and Hb EE are mild disorders. The combination of Hb E and Hb S (Hb SE) results in a sickle cell disease syndrome similar to sickle beta(+) thalassemia. It is important to distinguish Hb E disorders diagnostically because of this marked difference in clinical course among different genotypes. Screening tests… Expand
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TLDR
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A lower Hb E level in double heterozygotes with HbE and SEA-type alpha-thalassemia is confirmed, but the difference does not provide sufficient discriminatory power for the reliable exclusion of alpha-Thalassemia status. Expand
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