Hemoglobin dendrimers: functional protein clusters.

  title={Hemoglobin dendrimers: functional protein clusters.},
  author={Ronald Kluger and Jie Zhang},
  journal={Journal of the American Chemical Society},
  volume={125 20},
A cluster of cross-linked hemoglobin tetramers was prepared by conjugating active esters to amino groups of a starburst dendrimer. Comparison of oxygen-binding properties of the protein cluster to those of nonclustered species reveals an increase in affinity and a decrease in cooperativity in the cluster. The altered oxygen-binding properties are assigned to protein-protein interactions. 

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