Hemoglobin- and myoglobin-induced acute renal failure in rats: role of iron in nephrotoxicity.

@article{Paller1988HemoglobinAM,
  title={Hemoglobin- and myoglobin-induced acute renal failure in rats: role of iron in nephrotoxicity.},
  author={Mark S Paller},
  journal={The American journal of physiology},
  year={1988},
  volume={255 3 Pt 2},
  pages={F539-44}
}
  • Mark S Paller
  • Published 1988 in The American journal of physiology
In ischemic acute renal failure oxygen free radicals may mediate injury. In addition, iron appears to play a critical role in hydroxyl radical formation and lipid peroxidation during reperfusion of ischemic kidneys. To determine whether iron may play a similar role in pigment (heme protein)-induced acute renal failure, we studied the effects of the iron chelator deferoxamine in two experimental models of pigment-induced acute renal failure, intramuscular glycerol injection and intravenous… CONTINUE READING

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In another model of heme pigment - induced renal injury , hemoglobin was infused to produce hemoglobinuria .
Hemoglobin- and myoglobin - induced acute renal failure in rats : role of iron in nephrotoxicity .
Hemoglobin- and myoglobin - induced acute renal failure in rats : role of iron in nephrotoxicity .
Hemoglobin- and myoglobin - induced acute renal failure in rats : role of iron in nephrotoxicity .
Hemoglobin- and myoglobin - induced acute renal failure in rats : role of iron in nephrotoxicity .
To determine whether iron may play a similar role in pigment ( heme protein)-induced acute renal failure , we studied the effects of the iron chelator deferoxamine in two experimental models of pigment - induced acute renal failure , intramuscular glycerol injection and intravenous hemoglobin infusion without and with concurrent ischemia in the rat .
To determine whether iron may play a similar role in pigment ( heme protein)-induced acute renal failure , we studied the effects of the iron chelator deferoxamine in two experimental models of pigment - induced acute renal failure , intramuscular glycerol injection and intravenous hemoglobin infusion without and with concurrent ischemia in the rat .
To determine whether iron may play a similar role in pigment ( heme protein)-induced acute renal failure , we studied the effects of the iron chelator deferoxamine in two experimental models of pigment - induced acute renal failure , intramuscular glycerol injection and intravenous hemoglobin infusion without and with concurrent ischemia in the rat .
To determine whether iron may play a similar role in pigment ( heme protein)-induced acute renal failure , we studied the effects of the iron chelator deferoxamine in two experimental models of pigment - induced acute renal failure , intramuscular glycerol injection and intravenous hemoglobin infusion without and with concurrent ischemia in the rat .
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