Hemoglobin adducts and urinary mercapturic acids in rats as biological indicators of butadiene exposure.

@article{OstermanGolkar1991HemoglobinAA,
  title={Hemoglobin adducts and urinary mercapturic acids in rats as biological indicators of butadiene exposure.},
  author={Siv M Osterman-Golkar and A Kautiainen and E N Bergmark and Kjell H{\aa}kansson and Jorma M{\"a}ki-Paakkanen},
  journal={Chemico-biological interactions},
  year={1991},
  volume={80 3},
  pages={291-302}
}
Binding of 1,2-epoxy-3-butene, the primary metabolite of butadiene, to hemoglobin (Hb) and excretion of its mercapturic acid in urine were studied as potential indicators of butadiene exposure. Four groups of Wistar rats were exposed to butadiene at 0, 250, 500 and 1000 ppm 6 h/day, 5 days/week, during 2 weeks. Blood was collected at the end of exposure and 17 days later for analysis of hemoglobin adducts and adduct stability. Urine was collected each day during exposure (afternoon samples) and… CONTINUE READING

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