Hemoglobin Uptake by Paracoccidioides spp. Is Receptor-Mediated

  title={Hemoglobin Uptake by Paracoccidioides spp. Is Receptor-Mediated},
  author={Elisa Fl{\'a}via Luiz Cardoso Bail{\~a}o and Juliana Alves Parente and Laurine Lacerda Pigosso and Kelly Pacheco de Castro and Fernanda Lopes Fonseca and Mirelle Garcia Silva-Bail{\~a}o and S{\^o}nia Nair B{\'a}o and Alexandre Melo Bail{\~a}o and Marcio Lourenço Rodrigues and Orville Hern{\'a}ndez and Juan G Mcewen and C{\'e}lia Maria de Almeida Soares},
  booktitle={PLoS neglected tropical diseases},
Iron is essential for the proliferation of fungal pathogens during infection. The availability of iron is limited due to its association with host proteins. Fungal pathogens have evolved different mechanisms to acquire iron from host; however, little is known regarding how Paracoccidioides species incorporate and metabolize this ion. In this work, host iron sources that are used by Paracoccidioides spp. were investigated. Robust fungal growth in the presence of the iron-containing molecules… CONTINUE READING