• Chemistry, Medicine
  • Published in
    The Journal of biological…
    1968

Hemoglobin Kansas, a human hemoglobin with a neutral amino acid substitution and an abnormal oxygen equilibrium.

@article{Bonaventura1968HemoglobinKA,
  title={Hemoglobin Kansas, a human hemoglobin with a neutral amino acid substitution and an abnormal oxygen equilibrium.},
  author={Joseph Bonaventura and Austen Riggs},
  journal={The Journal of biological chemistry},
  year={1968},
  volume={243 5},
  pages={
          980-91
        }
}
Abstract The structure of an abnormal human hemoglobin with a low affinity for oxygen and little heme-heme interaction has been determined. Threonine replaces asparagine in position 102 of the β chain, which is the fourth residue of the G helix. Although this is a neutral substitution, the hemoglobin is nevertheless chromatographically and electrophoretically distinguishable from normal human hemoglobin. No other abnormality has been found. The tetrameric hemoglobin dissociates at least to a… CONTINUE READING

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Subunit dissociation of certain abnormal human hemoglobins.

  • The Journal of clinical investigation
  • 1969
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The Second and Third Hemoglobin Kansas Cases in the Turkish Population

  • Turkish journal of haematology : official journal of Turkish Society of Haematology
  • 2017
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Oxygen transport by hemoglobin.

  • Comprehensive Physiology
  • 2012
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