Hemoglobin-Induced Nitric Oxide Synthase Overexpression and Nitric Oxide Production Contribute to Blood–Brain Barrier Disruption in the Rat

@article{Yang2013HemoglobinInducedNO,
  title={Hemoglobin-Induced Nitric Oxide Synthase Overexpression and Nitric Oxide Production Contribute to Blood–Brain Barrier Disruption in the Rat},
  author={Shuo Yang and Yizhao Chen and Xinqing Deng and Weiping Jiang and Bing Li and Zhenghao Fu and Mouxuan Du and Rui Ding},
  journal={Journal of Molecular Neuroscience},
  year={2013},
  volume={51},
  pages={352-363}
}
Hemoglobin (Hb) released from extravasated erythrocytes may have a critical role in the process of blood–brain barrier (BBB) disruption and subsequent edema formation after intracerebral hemorrhage (ICH). Excessive nitric oxide (NO) production synthesized by nitric oxide synthase (NOS) has been well documented to contribute to BBB disruption. However, considerably less attention has been focused on the role of NO in Hb-induced BBB disruption. This study was designed to examine the hypothesis… CONTINUE READING
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