Hemoglobin Grange-Blanche [beta 27(B9) Ala----Val], a new variant with normal expression and increased affinity for oxygen.

@article{Baklouti1987HemoglobinG,
  title={Hemoglobin Grange-Blanche [beta 27(B9) Ala----Val], a new variant with normal expression and increased affinity for oxygen.},
  author={Faouzi Baklouti and Y Giraud and Alain Francina and Gabriela Richard and C. Perier and Andr{\'e} Geyssant and Jean Jaubert and Christian Pierre Brizard and Jean Delaunay},
  journal={FEBS letters},
  year={1987},
  volume={223 1},
  pages={59-62}
}
Hemoglobin Grange-Blanche [beta 27(B9) Ala----Val] is a new variant found in a Portuguese family. The carriers present moderate erythrocytosis. Upon isoelectric focusing, Hb Grange-Blanche was slightly more cathodic than Hb A. beta Grange-Blanche chain migrated like the G gamma chain when submitted to electrophoresis in the presence of urea-Triton X-100. The precentage of Hb Grange-Blanche was about 50% in the heterozygous state. Oxygen affinity was increased (P50 = 22 mmHg), but heme-heme… CONTINUE READING

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