Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms.

Abstract

Recent studies have shown that nascent hematopoietic stem cells (HSCs) derive directly from the ventral aortic endothelium (VAE) via endothelial to hematopoietic transition (EHT). However, whether EHT initiates from a random or predetermined subpopulation of VAE, as well as the molecular mechanism underlying this process, remain unclear. We previously… (More)
DOI: 10.1242/dev.097071

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