Hemodynamics and tissue oxygenation after hemodilution with ultrahigh molecular weight polymerized albumin.

@article{Castro2014HemodynamicsAT,
  title={Hemodynamics and tissue oxygenation after hemodilution with ultrahigh molecular weight polymerized albumin.},
  author={Claudia Castro and Daniel Ortiz and Andre Francis Palmer and Pedro J. Cabrales},
  journal={Minerva anestesiologica},
  year={2014},
  volume={80 5},
  pages={
          537-46
        }
}
BACKGROUND Compared to blood transfusion, plasma expanders (PEs) are more cost effective, have a longer shelf-life, and elicit a milder immune response. High molecular weight (MW) dextrans preserve microvascular function during extreme hemodilution. Dextrans, however, evokes negative hemostatic effects, including red blood cell (RBC) aggregation and reduce platelet adhesion, that limit their clinical use. Therefore, polymerization of human serum albumin (HSA) presents a simple strategy to… CONTINUE READING