Hemodynamics, biochemical effects, and pharmacokinetics of the renin inhibitor remikiren in healthy human subjects.

@article{Kleinbloesem1993HemodynamicsBE,
  title={Hemodynamics, biochemical effects, and pharmacokinetics of the renin inhibitor remikiren in healthy human subjects.},
  author={C. H. Kleinbloesem and Cora Weber and E M Fahrner and M Dellenbach and Horst Welker and Volker H. Schroeter and Gustav Georg Belz},
  journal={Clinical pharmacology and therapeutics},
  year={1993},
  volume={53 5},
  pages={585-92}
}
INTRODUCTION Remikiren (Ro 42-5892) is a potent and specific inhibitor of human renin in vitro. Its in vivo action on plasma renin activity (PRA), immunoreactive renin, and blood pressure has been shown in pilot studies in humans. OBJECTIVE To investigate tolerability, hemodynamic effects, and biochemical effects of remikiren in relation to its… CONTINUE READING