Hemodynamic shear stress and its role in atherosclerosis.

@article{Malek1999HemodynamicSS,
  title={Hemodynamic shear stress and its role in atherosclerosis.},
  author={Adel M. Malek and Seth L Alper and Seigo Izumo},
  journal={JAMA},
  year={1999},
  volume={282 21},
  pages={2035-42}
}
Atherosclerosis, the leading cause of death in the developed world and nearly the leading cause in the developing world, is associated with systemic risk factors including hypertension, smoking, hyperlipidemia, and diabetes mellitus, among others. Nonetheless, atherosclerosis remains a geometrically focal disease, preferentially affecting the outer edges of vessel bifurcations. In these predisposed areas, hemodynamic shear stress, the frictional force acting on the endothelial cell surface as a… CONTINUE READING
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