Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study.

@article{Franklin1997HemodynamicPO,
  title={Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study.},
  author={Stanley S. Franklin and W Gustin and Nathan D. Wong and Martin G. Larson and Michael A. Weber and W. B. Kannel and Daniel Levy},
  journal={Circulation},
  year={1997},
  volume={96 1},
  pages={
          308-15
        }
}
BACKGROUND We attempted to characterize age-related changes in blood pressure in both normotensive and untreated hypertensive subjects in a population-based cohort from the original Framingham Heart Study and to infer underlying hemodynamic mechanisms. [] Key Method After excluding subjects receiving antihypertensive drug therapy, up to 30 years of data on normotensive and untreated hypertensive subjects from biennial examinations 2 through 16 were used.

Pulse Pressure: A Predictor of Cardiovascular Mortality Among Young Normotensive Subjects

Among young subjects, but not older normotensive persons, at very low risk of cardiovascular disease, a wide pulse pressure is associated with increased cardiovascular mortality.

Conventional Antihypertensive Drug Therapy Does Not Prevent the Increase of Pulse Pressure With Age

In the studied populations, the increase of PP with age is independent of gender and of the presence of antihypertensive drug treatment, leading to an increased prevalence of ISH and a subsequent increase of cardiovascular risk with age.

Role of Vascular Adaptation in Determining Systolic Blood Pressure in Young Adults

Increased PVR, mediated in part through altered resistance vessel structure, strongly associates with the elevation of SBP for a given level of PP in young adults, suggesting an impaired ability to adapt PVR appropriately to a givenlevel of PP may be an important mechanism underlying elevated SBP in young Adults.

Altered Age-Related Blood Pressure Pattern in Type 1 Diabetes

A higher systolic pressure and an earlier decrease in diastolic pressure result in a higher and more rapidly increasing PP in type 1 diabetic patients, which may contribute to the higher cardiovascular morbidity and mortality in patients.

Systolic and Diastolic Blood Pressure Lowering as Determinants of Cardiovascular Outcome

It is suggested that antihypertensive drug treatment improves outcome mainly through lowering of systolic blood pressure, and absolute benefit increased with age and with lower ratio of DBP to SBP lowering.

Aging, blood pressure, and heart failure: what are the connections?

In Framingham Heart Study participants who were free of CVD and not receiving BP-lowering therapy, SBP and DBP in combination produced a model that was superior to any single BP component alone in predicting total CVD events (coronary heart disease, heart failure, and stroke).

Arterial stiffness, not systolic blood pressure, increases with age in native Papuan populations

Systolic blood pressure (SBP) and arterial stiffness are closely related and may behave reciprocally as cause or effect, interacting in a vicious cycle, but the age-related changes in these measurements differed in this highland Papuan population.

Uric acid and fibrinogen: age-modulated relationships with blood pressure components

Findings add evidence concerning an age-modulated relationship between the levels of uric acid and fibrinogen and the steady and pulsatile components of BP and it is possibly related to the different mechanisms underlying increased BP: renal factors in middle-aged subjects and vascular abnormalities in the elderly.

Age-dependent associations between blood pressure and coronary artery calcification in asymptomatic adults

SBP, DBP and PP have age-dependent roles in the prediction of CAC similar to their roles in prediction of future CAD events, and these observations provide new evidence supporting the measurement of Cac as a surrogate of target organ disease and subsequently, as a predictor of increased risk of Future CAD events.

Effects of cardiorespiratory fitness on blood pressure trajectory with aging in a cohort of healthy men.

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