Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study.

  title={Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study.},
  author={Stanley S. Franklin and W Gustin and Nathan D. Wong and Martin G. Larson and Michael A. Weber and W. B. Kannel and Daniel Levy},
  volume={96 1},
BACKGROUND We attempted to characterize age-related changes in blood pressure in both normotensive and untreated hypertensive subjects in a population-based cohort from the original Framingham Heart Study and to infer underlying hemodynamic mechanisms. [] Key Method After excluding subjects receiving antihypertensive drug therapy, up to 30 years of data on normotensive and untreated hypertensive subjects from biennial examinations 2 through 16 were used.

Pulse Pressure: A Predictor of Cardiovascular Mortality Among Young Normotensive Subjects

Among young subjects, but not older normotensive persons, at very low risk of cardiovascular disease, a wide pulse pressure is associated with increased cardiovascular mortality.

Conventional Antihypertensive Drug Therapy Does Not Prevent the Increase of Pulse Pressure With Age

In the studied populations, the increase of PP with age is independent of gender and of the presence of antihypertensive drug treatment, leading to an increased prevalence of ISH and a subsequent increase of cardiovascular risk with age.

Role of Vascular Adaptation in Determining Systolic Blood Pressure in Young Adults

Increased PVR, mediated in part through altered resistance vessel structure, strongly associates with the elevation of SBP for a given level of PP in young adults, suggesting an impaired ability to adapt PVR appropriately to a givenlevel of PP may be an important mechanism underlying elevated SBP in young Adults.

Altered Age-Related Blood Pressure Pattern in Type 1 Diabetes

A higher systolic pressure and an earlier decrease in diastolic pressure result in a higher and more rapidly increasing PP in type 1 diabetic patients, which may contribute to the higher cardiovascular morbidity and mortality in patients.

Systolic and Diastolic Blood Pressure Lowering as Determinants of Cardiovascular Outcome

It is suggested that antihypertensive drug treatment improves outcome mainly through lowering of systolic blood pressure, and absolute benefit increased with age and with lower ratio of DBP to SBP lowering.

Aging, blood pressure, and heart failure: what are the connections?

In Framingham Heart Study participants who were free of CVD and not receiving BP-lowering therapy, SBP and DBP in combination produced a model that was superior to any single BP component alone in predicting total CVD events (coronary heart disease, heart failure, and stroke).

Arterial stiffness, not systolic blood pressure, increases with age in native Papuan populations

Systolic blood pressure (SBP) and arterial stiffness are closely related and may behave reciprocally as cause or effect, interacting in a vicious cycle, but the age-related changes in these measurements differed in this highland Papuan population.

Uric acid and fibrinogen: age-modulated relationships with blood pressure components

Findings add evidence concerning an age-modulated relationship between the levels of uric acid and fibrinogen and the steady and pulsatile components of BP and it is possibly related to the different mechanisms underlying increased BP: renal factors in middle-aged subjects and vascular abnormalities in the elderly.

Age-dependent associations between blood pressure and coronary artery calcification in asymptomatic adults

SBP, DBP and PP have age-dependent roles in the prediction of CAC similar to their roles in prediction of future CAD events, and these observations provide new evidence supporting the measurement of Cac as a surrogate of target organ disease and subsequently, as a predictor of increased risk of Future CAD events.

Effects of cardiorespiratory fitness on blood pressure trajectory with aging in a cohort of healthy men.




Determinants of isolated systolic hypertension.

It is concluded that ISH is a highly prevalent disorder whose major determinants are age, sex, increasing levels of blood pressure, and obesity in women.

Determinants of isolated systolic hypertension in the elderly

  • W. NicholsF. NicoliniC. Pepine
  • Medicine, Biology
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension
  • 1992
The changes in impedance spectra in the isolated systolic hypertensives indicate that the cross-sectional area of the peripheral vascular bed was reduced and that the aorta and large arteries were stiffer, producing an increased pulse wave velocity and an early return of pulse wave reflection in systole.

Twenty‐Year Follow‐up of Hemodynamics in Essential Hypertension During Rest and Exercise

The study has shown a progressively abnormal hemodynamic pattern over two decades in patients of different ages with essential hypertension, with a marked increase in total peripheral resistance and fall in cardiac index and stroke index in this age group treated over 20 years.

Influence of sex on arterial hemodynamics and blood pressure. Role of body height.

Arsenial function was studied to assess the possibility that systolic pressure differences in women are related to smaller body size, and in premenopausal women the distensibility of brachial and femoral arteries was higher than in age-matched men, whereas aortic Distensibility was not different.

Remission of hypertension. The 'natural' history of blood pressure treatment in the Framingham Study.

While virtually all hypertensive subjects eventually relapse, a small group may experience a period of remission of hypertension while not receiving medication, and guidelines for medical care of hypertensive persons will need to be updated.

The natural history of borderline isolated systolic hypertension.

In both the short term and the long term, subjects with borderline isolated systolic hypertension are at increased risk of progression to definite hypertension and the development of cardiovascular disease.

Systolic hypertension in the elderly. Hemodynamic response to long-term thiazide diuretic therapy and its side effects.

Thiazide therapy effectively and safely lowers the BP in most patients with systolic hypertension by reducing systemic vascular resistance.