Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study.

@article{Franklin1997HemodynamicPO,
  title={Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study.},
  author={S. Franklin and W. Gustin and N. Wong and M. Larson and M. Weber and W. Kannel and D. Levy},
  journal={Circulation},
  year={1997},
  volume={96 1},
  pages={
          308-15
        }
}
BACKGROUND We attempted to characterize age-related changes in blood pressure in both normotensive and untreated hypertensive subjects in a population-based cohort from the original Framingham Heart Study and to infer underlying hemodynamic mechanisms. [...] Key Method After excluding subjects receiving antihypertensive drug therapy, up to 30 years of data on normotensive and untreated hypertensive subjects from biennial examinations 2 through 16 were used.Expand
Pulse Pressure: A Predictor of Cardiovascular Mortality Among Young Normotensive Subjects
TLDR
Among young subjects, but not older normotensive persons, at very low risk of cardiovascular disease, a wide pulse pressure is associated with increased cardiovascular mortality. Expand
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Role of Vascular Adaptation in Determining Systolic Blood Pressure in Young Adults
TLDR
Increased PVR, mediated in part through altered resistance vessel structure, strongly associates with the elevation of SBP for a given level of PP in young adults, suggesting an impaired ability to adapt PVR appropriately to a givenlevel of PP may be an important mechanism underlying elevated SBP in young Adults. Expand
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TLDR
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Aging, blood pressure, and heart failure: what are the connections?
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Uric acid and fibrinogen: age-modulated relationships with blood pressure components
TLDR
Findings add evidence concerning an age-modulated relationship between the levels of uric acid and fibrinogen and the steady and pulsatile components of BP and it is possibly related to the different mechanisms underlying increased BP: renal factors in middle-aged subjects and vascular abnormalities in the elderly. Expand
Age-dependent associations between blood pressure and coronary artery calcification in asymptomatic adults
TLDR
SBP, DBP and PP have age-dependent roles in the prediction of CAC similar to their roles in prediction of future CAD events, and these observations provide new evidence supporting the measurement of Cac as a surrogate of target organ disease and subsequently, as a predictor of increased risk of Future CAD events. Expand
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The findings underscore the potential modifying effect of fitness on BP trajectory with aging over the male adult life span, and suggest improving fitness levels might extend the normal SBP and DBP ranges, delaying the development of hypertension. Expand
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