Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats.

@article{Trebicka2008HemodynamicEO,
  title={Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats.},
  author={Jonel Trebicka and Ludger Leifeld and Martin Hennenberg and Erwin Biecker and Andreas Eckhardt and Nicolas Fischer and Andrea Schulze Pr{\"o}bsting and Christoph Clemens and Frank Lammert and Tilman Sauerbruch and Joerg Heller},
  journal={Hepatology},
  year={2008},
  volume={47 4},
  pages={1264-76}
}
UNLABELLED In cirrhosis, splanchnic vasodilation contributes to portal hypertension, subsequent renal sodium retention, and formation of ascites. Urotensin II(U-II) is a constrictor of large conductive vessels. Conversely, it relaxes mesenteric vessels, decreases glomerular filtration, and increases renal sodium retention. In patients with cirrhosis, U-II plasma levels are increased. Thus, we investigated hemodynamic and renal effects of U-II and its receptor antagonist, palosuran, in cirrhotic… CONTINUE READING