Hemodynamic effects of intracoronary VEGF delivery: evidence of tachyphylaxis and NO dependence of response.

@article{Lopez1997HemodynamicEO,
  title={Hemodynamic effects of intracoronary VEGF delivery: evidence of tachyphylaxis and NO dependence of response.},
  author={John J. Lopez and Rojer J Laham and Joseph P. Carrozza and Motohisa Tofukuji and Frank W Sellke and Stuart Bunting and Michael Simons},
  journal={The American journal of physiology},
  year={1997},
  volume={273 3 Pt 2},
  pages={H1317-23}
}
Vascular endothelial growth factor (VEGF) has been utilized to improve blood flow in the setting of myocardial or peripheral vascular ischemia. In this investigation we studied the hemodynamic effects of intracoronary VEGF administration. Hemodynamic parameters and Doppler flow wire recordings from the left anterior descending coronary artery were measured after intracoronary infusion of VEGF (1, 10, and 100 micrograms) in 28 intubated pigs. Additional studies were performed using an in vitro… CONTINUE READING

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