Hemodynamic effects of ephedrine, phenylephrine, and the coadministration of phenylephrine with oxytocin during spinal anesthesia for elective cesarean delivery.

@article{Dyer2009HemodynamicEO,
  title={Hemodynamic effects of ephedrine, phenylephrine, and the coadministration of phenylephrine with oxytocin during spinal anesthesia for elective cesarean delivery.},
  author={Robert Anthony Dyer and Anthony R Reed and Dominique van Dyk and Michelle J Arcache and Owen Hodges and Carl J. Lombard and Jaime Greenwood and Michael F M James},
  journal={Anesthesiology},
  year={2009},
  volume={111 4},
  pages={753-65}
}
BACKGROUND Hemodynamic responses to vasopressors used during spinal anesthesia for elective Cesarean delivery, have not been well described. This study compared the effects of bolus phenylephrine and ephedrine on maternal cardiac output (CO). The hypothesis was that phenylephrine, but not ephedrine, decreases CO when administered in response to hypotension during spinal anesthesia. METHODS Forty-three patients were randomized to receive 80 microg of phenylephrine or 10 mg of ephedrine. Both… CONTINUE READING

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