Hemodynamic effects of cadralazine or chlorthalidone in verapamil-treated elderly hypertensives.

@article{Antonicelli1994HemodynamicEO,
  title={Hemodynamic effects of cadralazine or chlorthalidone in verapamil-treated elderly hypertensives.},
  author={Roberto Antonicelli and Stefano Savonitto and Paolo Tomassini and Claudio Gambini and Marco Sardina and Enrico Paciaroni},
  journal={International journal of clinical pharmacology and therapeutics},
  year={1994},
  volume={32 4},
  pages={198-203}
}
Fourteen hypertensives aged > 66-77 years, whose diastolic blood pressure (DBP) was > or = 95 mmHg at the end of 1-month treatment with verapamil 240 mg SR, took part in this clinical-hemodynamic study. Patients were randomized to add the long-acting hydralazine derivative, cadralazine, 10 mg once daily, or chlorthalidone 25 mg once daily for 1 month each, to their previous verapamil regimen, according to a double-blind crossover design. Echo-Doppler hemodynamics were performed before starting… CONTINUE READING

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