Hemodynamic effects of bPTH(1-34) and its analogue Nle8,18Tyr34bPTH(3-34) amide.

  title={Hemodynamic effects of bPTH(1-34) and its analogue Nle8,18Tyr34bPTH(3-34) amide.},
  author={John T. Daugirdas and R R Al-Kudsi and Todd S. Ing and Mei C Yang and David J. Leehey and Peter K. T. Pang},
  journal={Mineral and electrolyte metabolism},
  volume={13 1},
We examined the vascular effects of bovine PTH(1-34) and of an analogue, Nle8,18Tyr34bPTH(3-34) amide, which inhibits adenylate cyclase activation by bPTH(1-34) in a number of in vitro systems. In the conscious dog. bPTH(1-34) injection produced dose-dependent hypotension associated with increased heart rate and cardiac output. The (3-34) analogue had no hypotensive effect in doses up to 6.0 micrograms/kg (1.5 nM/kg). In vitro studies revealed that bPTH(1-34) relaxed pitressin-contracted… CONTINUE READING

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