Hemodynamic effects of an intravenous infusion of medetomidine at six different dose regimens in isoflurane-anesthetized dogs.

@article{Kaartinen2010HemodynamicEO,
  title={Hemodynamic effects of an intravenous infusion of medetomidine at six different dose regimens in isoflurane-anesthetized dogs.},
  author={Johanna Kaartinen and Daniel Pang and Maxim Moreau and Outi Vainio and Francis Beaudry and J{\'e}r{\^o}me R E Del Castillo and Leigh A. Lamont and Sophie G Cuvelliez and Eric Troncy},
  journal={Veterinary therapeutics : research in applied veterinary medicine},
  year={2010},
  volume={11 1},
  pages={E1-16}
}
This study investigated the dose dependency of the hemodynamic effects of IV medetomidine (MED) constant-rate infusion (CRI) during isoflurane anesthesia. Twenty-four healthy beagles randomly received one of six MED CRI regimens. A loading dose of MED was administered IV at 0.2, 0.5, 1.0, 1.7, 4.0, or 12.0 ug/kg-1 for 10 minutes, followed by a maintenance CRI providing identical dose amounts over 60 minutes. Heart rate and mean arterial blood pressure were recorded, blood gases were analyzed… CONTINUE READING