Hemodynamic changes induced by low blood oxygen affinity in dogs.

@article{Liard1993HemodynamicCI,
  title={Hemodynamic changes induced by low blood oxygen affinity in dogs.},
  author={J F Liard and Mary Pat Kunert},
  journal={The American journal of physiology},
  year={1993},
  volume={264 2 Pt 2},
  pages={
          R396-401
        }
}
Increased tissue oxygen delivery may play a role in the increased vascular resistance that develops in volume-expanded hypertension. This hypothesis was tested by decreasing the affinity of hemoglobin for oxygen in dogs to increase unloading of oxygen to the tissues. Six chronically instrumented dogs were studied before and for 7 days after partial exchange transfusion with red blood cells modified by incorporation of inositol hexaphosphate, which, 1 h after exchange, increased the PO2 value at… CONTINUE READING

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