Hemodynamic and neurohumoral effects of levosimendan, a new calcium sensitizer, at rest and during exercise in healthy men.

@article{Sundberg1995HemodynamicAN,
  title={Hemodynamic and neurohumoral effects of levosimendan, a new calcium sensitizer, at rest and during exercise in healthy men.},
  author={S. H. Sundberg and Jyrki M. Lilleberg and Markku S Nieminen and Lasse Lehtonen},
  journal={The American journal of cardiology},
  year={1995},
  volume={75 15},
  pages={1061-6}
}
Levosimendan is a novel inodilator that increases the calcium sensitivity of troponin C in a calcium-dependent way. Cardiac function (impedance cardiography, systolic time intervals), neurohumoral responses at rest and during exercise at 2 workloads, and peripheral blood flow (plethysmography) were studied in 14 healthy young men. Vehicle and 2 doses of levosimendan (6.5 micrograms/kg, low dose [LD]; and 25 micrograms/kg, high dose [HD]) were given intravenously in a crossover study… CONTINUE READING

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