Hemodynamic and neuroendocrine responses to acute and chronic alpha-adrenergic blockade with prazosin and phenoxybenzamine.

@article{MULVIHILLWILSON1983HemodynamicAN,
  title={Hemodynamic and neuroendocrine responses to acute and chronic alpha-adrenergic blockade with prazosin and phenoxybenzamine.},
  author={JULIA MULVIHILL-WILSON and F. Andrew Gaffney and William A. Pettinger and C. Gunnar Blomqvist and Sharon Anderson and Robert M. Graham},
  journal={Circulation},
  year={1983},
  volume={67 2},
  pages={383-93}
}
We investigated the relevance of the selective alpha 1-adrenergic receptor blockade produced by prazosin to its blood pressure-lowering efficacy in man. The hemodynamic and neuroendocrine responses to the acute and chronic oral administration of prazosin and phenoxybenzamine were compared in a randomized, double-blind, placebo-controlled, crossover study of 11 patients with essential hypertension. These responses were also evaluated during lower body negative pressure and dynamic bicycle… CONTINUE READING

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