Hemodynamic and clinical evaluation of piroximone, a new inotrope-vasodilator agent, in severe congestive heart failure.

@article{Axelrod1987HemodynamicAC,
  title={Hemodynamic and clinical evaluation of piroximone, a new inotrope-vasodilator agent, in severe congestive heart failure.},
  author={Robert Axelrod and Teresa de Marco and Michael W. Dae and Elias H. Botvinick and Kanu Chatterjee},
  journal={Journal of the American College of Cardiology},
  year={1987},
  volume={9 5},
  pages={1124-30}
}
To assess the potential utility of piroximone (MDL-19,205), an investigational inotrope-vasodilator agent, in severe heart failure, 15 patients with severe left ventricular failure refractory to conventional agents were enrolled in an acute hemodynamic study. After incremental intravenous dosing (mean total dose 1.8 +/- 0.4 mg/kg body weight), cardiac index increased (1.7 +/- 0.3 to 2.6 +/- 0.6 liters/min per m2; p less than 0.001) and left ventricular filling pressure decreased (25 +/- 7 to 19… CONTINUE READING