Hemodynamic actions of nicorandil, a new antianginal agent, in the conscious dog.

@article{Preuss1985HemodynamicAO,
  title={Hemodynamic actions of nicorandil, a new antianginal agent, in the conscious dog.},
  author={Klaus Preuss and Garrett Gross and Harold L. Brooks and David C. Warltier},
  journal={Journal of cardiovascular pharmacology},
  year={1985},
  volume={7 4},
  pages={709-14}
}
We studied the hemodynamic effects of nicorandil (SG-75) and nitroglycerin in conscious dogs before and after beta-adrenergic receptor blockade. Nicorandil (25-300 micrograms/kg/min) and nitroglycerin (5-60 micrograms/kg/min) produced increases in heart rate and decreases in aortic and left ventricular pressures. In the doses studied, nicorandil caused greater decreases in aortic and left ventricular systolic pressure than nitroglycerin; however, nitroglycerin reduced left ventricular end… CONTINUE READING

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