Hemodynamic Determinants of the Time-Course of Fall in Canine Left Ventricular Pressure

Abstract

no significant change in T, but norepinephrine, which accelerates active relaxation, resulted in a significant shortening of T (65.6±13.4 vs. 46.3+7.0 ms, P < 0.02). This work was presented in part at the 47th Scientific Sessions of the American Heart Association, Dallas, Texas, 1974. Dr. Weiss holds the Frank T. McClure Fellowship in Cardiovascular Research at the Johns Hopkins University. Dr. Weisfeldt is an Established Investigator of the American Heart Association. Received for publication 29 December 1975 and in resised formii 4 May 1976. During recovery from ischemia, T increased significantly from 59.0±9.6 to 76.8+13.1 ms when compared vith the preischemic control beat (P < 0.05). Thus, the present studies show that the time-course of isovolumic pressure fall subsequent to maximum negative dP/dt is exponential, independent of systolic stress and end-systolic fiber length, and minimally dependent on heart rate. T may be an index of the activity of the active cardiac relaxing system and appears dependent on systolic fiber shortening

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Cite this paper

@inproceedings{Belfer2013HemodynamicDO, title={Hemodynamic Determinants of the Time-Course of Fall in Canine Left Ventricular Pressure}, author={Peter Belfer}, year={2013} }