Hemodialyzability of sertraline.

  title={Hemodialyzability of sertraline.},
  author={Michael H Schwenk and Maurizio Verga and Janice D. Wagner},
  journal={Clinical nephrology},
  volume={44 2},
Sertraline is an antidepressant which selectively inhibits the neuronal uptake of serotonin in the central nervous system. The pharmacokinetics of sertraline in end-stage renal disease (ESRD) and the effect of hemodialysis on sertraline clearance is unknown. A dose of 100 mg sertraline was administered to two anuric hemodialysis patients after hemodialysis. During the next hemodialysis session, simultaneous pre- and post dialyzer blood samples were obtained at the start of and hourly throughout… CONTINUE READING