Hemodialysis encephalopathy with osteomalacic fractures and muscle weakness.

  title={Hemodialysis encephalopathy with osteomalacic fractures and muscle weakness.},
  author={Alkis M Pierides and William H. Edwards and U X Cullum and John T Mccall and H. A. Ellis},
  journal={Kidney international},
  volume={18 1},
The hemodialysis unit at Columbia, South Carolina, opened in April, 1974. By June of 1977, 7 patients had died from dialysis encephalopathy, and 16 of the 51 surviving patients showed speech disorders, fits, and myoclonic jerks. Pathologic fractures were seen in 22 patients. Bone histomorphometry showed severe osteomalacia with minimal, if any, osteitis fibrosa, and serum alkaline phosphatase activity was normal. The mean serum aluminum concentration in 33 random patients was elevated at 83.5… CONTINUE READING