Hemocyte differentiation mediates the mosquito late-phase immune response against Plasmodium in Anopheles gambiae.

@article{Smith2015HemocyteDM,
  title={Hemocyte differentiation mediates the mosquito late-phase immune response against Plasmodium in Anopheles gambiae.},
  author={Ryan C. Smith and Carolina Barillas-Mury and Marcelo Jacobs-Lorena},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 26},
  pages={E3412-20}
}
Plasmodium parasites must complete development in the mosquito vector for transmission to occur. The mosquito innate immune response is remarkably efficient in limiting parasite numbers. Previous work has identified a LPS-induced TNFα transcription factor (LITAF)-like transcription factor, LITAF-like 3 (LL3), which significantly influences parasite numbers. Here, we demonstrate that LL3 does not influence invasion of the mosquito midgut epithelium or ookinete-to-oocyst differentiation but… CONTINUE READING

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