Hemochromatosis-causing mutations C282Y and H63D are not risk factors for atherothrombotic cerebral infarction.

BACKGROUND It has been suggested that iron metabolism may be involved in the pathogenesis of atherothrombotic cerebral infarction (ACI). The C282Y and H63D mutations in the hemochromatosis (HFE) gene are associated with increased serum iron levels and net iron accumulation. The aim of this study was to test the hypothesis that the C282Y and H63D mutations… CONTINUE READING