Hemispheric Brain Injury and Behavioral Deficits Induced by Severe Neonatal Hypoxia-Ischemia in Rats Are Not Attenuated by Intravenous Administration of Human Umbilical Cord Blood Cells

@article{Paula2009HemisphericBI,
  title={Hemispheric Brain Injury and Behavioral Deficits Induced by Severe Neonatal Hypoxia-Ischemia in Rats Are Not Attenuated by Intravenous Administration of Human Umbilical Cord Blood Cells},
  author={S. F. de Paula and Affonso Santos Vitola and Samuel Greggio and Davi de Paula and P{\^a}mela Billig Mello and Jeremiah Mistrello Lubianca and L{\'e}der Leal Xavier and Humberto Holmer Fiori and Jaderson Costa Dacosta},
  journal={Pediatric Research},
  year={2009},
  volume={65},
  pages={631-635}
}
Neonatal hypoxia-ischemia (HI) is an important cause of mortality and morbidity in infants. Human umbilical cord blood (HUCB) is a potential source of cellular therapy in perinatology. We investigated the effects of HUCB cells on spatial memory, motor performance, and brain morphologic changes in neonate rats submitted to HI. Seven-day-old rats underwent right carotid artery occlusion followed by exposure to 8% O2 inhalation for 2 h. Twenty-four hours after HI, rats received either saline… CONTINUE READING
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