Hemin modulates cytokine expressions in macrophage-derived foam cells via heme oxygenase-1 induction.

@article{Ma2007HeminMC,
  title={Hemin modulates cytokine expressions in macrophage-derived foam cells via heme oxygenase-1 induction.},
  author={Jian-li Ma and Pengyuan Y. Yang and Yao-cheng Rui and Ling Lu and Hui Kang and Jing Zhang},
  journal={Journal of pharmacological sciences},
  year={2007},
  volume={103 3},
  pages={261-6}
}
Lipid-laden foam cells were considered to be targets for therapeutic intervention in atherosclerosis. Several studies proposed new approaches to alter both lipid accumulation and inflammatory responses in macrophages. Finding anti-inflammatory signals during foam cell formation would provide new valid targets for anti-atherosclerotic treatment. The aim of the present study was to see whether oxidized low-density lipoprotein (ox-LDL) can active heme oxygenase (HO)-1 expression level in a human… CONTINUE READING

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