Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors.

@article{Kim2001HemininducedAO,
  title={Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors.},
  author={Yoon Cheong Kim and Hiroshi Masutani and Yu Yamaguchi and Keiji Itoh and Masayuki Yamamoto and Junji Yodoi},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 21},
  pages={18399-406}
}
Thioredoxin plays an important role in various cellular processes through redox regulation. Here, we have demonstrated that thioredoxin expression is transcriptionally induced in K562 cells by hemin (ferriprotoporphyrin IX) through activation of a regulatory region positioned from -452 to -420 bp of the thioredoxin gene. Insertion of a mutation in the antioxidant responsive element (ARE)/AP-1 consensus binding sequence in this region abolished the response to hemin. With electrophoretic… CONTINUE READING

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