Hemin binding and oxidation of lipoproteins in serum: mechanisms and effect on the interaction of LDL with human macrophages.

@article{Camejo1998HeminBA,
  title={Hemin binding and oxidation of lipoproteins in serum: mechanisms and effect on the interaction of LDL with human macrophages.},
  author={Germ{\'a}n Camejo and C Halberg and A Manschik-Lundin and Eva Hurt-Camejo and Birgitta Rosengren and H. K. Olsson and G{\"o}ran I. Hansson and G B Forsberg and B Ylhen},
  journal={Journal of lipid research},
  year={1998},
  volume={39 4},
  pages={755-66}
}
Most models of lipoprotein oxidation by free radicals have excluded macromolecular plasma components from the system. This limits their biological significance because oxidation of lipoproteins appears to occur in the intima in the presence of a plasma ultrafiltrate. Hemin, a product of in vivo hemoglobin degradation, binds and oxidizes purified lipoproteins. However, it is not known whether this occurs in the presence of plasma components that may sequester hemin. We found that hemin in serum… CONTINUE READING

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