Hemin and L-arginine regulation of blood pressure in spontaneous hypertensive rats.

@article{Martasek1991HeminAL,
  title={Hemin and L-arginine regulation of blood pressure in spontaneous hypertensive rats.},
  author={P Martasek and Michal Laniado Schwartzman and Alvin I Goodman and K B Solangi and Richard D. Levere and Nader G Abraham},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1991},
  volume={2 6},
  pages={
          1078-84
        }
}
Perturbation in heme metabolism is known to affect the level and activity of hemoproteins, including cytochrome P450-dependent arachidonic acid metabolism. The latter has been associated with elevation in blood pressure seen in spontaneously hypertensive rats. The effect of heme arginate and its components, arginine and heme, on cytochrome P450 levels and blood pressure in spontaneously hypertensive rats were studied. Administration of heme arginate or heme alone at doses of 9 to 30 mg/kg body… CONTINUE READING

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