Hemichannels in cardiomyocytes open transiently during ischemia and contribute to reperfusion injury following brief ischemia.

  title={Hemichannels in cardiomyocytes open transiently during ischemia and contribute to reperfusion injury following brief ischemia.},
  author={Kaori Shintani-Ishida and Koichi Uemura and Ken-ichi Yoshida},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={293 3},
The aim of this study was to investigate changes in hemichannel activity during in vitro simulated ischemia [oxygen-glucose deprivation (OGD)] and the contribution of hemichannels to ischemia-reperfusion injury in rat neonatal cardiomyocytes. Dye uptake assays showed that hemichannels opened as OGD progressed, peaking after 1 h, and then closed, returning to the pre-OGD state after 2 h of OGD. The increase in dye uptake after 1 h of OGD was inhibited by hemichannel blockers (lanthanum chloride… 

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