Hemichannel-mediated inhibition in the outer retina.

@article{Kamermans2001HemichannelmediatedII,
  title={Hemichannel-mediated inhibition in the outer retina.},
  author={Maarten Kamermans and Iris Fahrenfort and Konrad Schultz and Ulrike Janssen-Bienhold and Trijntje Sjoerdsma and Reto Weiler},
  journal={Science},
  year={2001},
  volume={292 5519},
  pages={
          1178-80
        }
}
An essential feature of the first synapse in the retina is a negative feedback pathway from horizontal cells to cones. Here we show that at this synapse, connexin26 forms hemichannels on horizontal cell dendrites near the glutamate release site of the cones. Blocking these hemichannels hyperpolarizes horizontal cells, modulates the Ca2+ channels of the cones, and abolishes all feedback-mediated responses. We propose a feedback mechanism in which the activity of the Ca2+ channels and the… CONTINUE READING
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