Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin

@article{Escobar2017HemiSynthesisAA,
  title={Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin},
  author={B. Escobar and I. Montenegro and Joan Villena and E. Werner and P. Godoy and Y. Olgu{\'i}n and A. Madrid},
  journal={Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry},
  year={2017},
  volume={22}
}
An efficient synthesis of a series of 4′-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by 1H-NMR, 13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them… Expand
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