Heme sensing in Bacillus thuringiensis: a supplementary HssRS-regulated heme resistance system.

  title={Heme sensing in Bacillus thuringiensis: a supplementary HssRS-regulated heme resistance system.},
  author={Rachel M Schmidt and Micaela M Carter and Michelle L Chu and Casey J. Latario and Sarah K Stadler and Devin L. Stauff},
  journal={FEMS microbiology letters},
  volume={363 9}
  • Rachel M Schmidt, Micaela M Carter, +3 authors Devin L. Stauff
  • Published 2016
  • Biology, Medicine
  • FEMS microbiology letters
  • Several Gram-positive pathogens scavenge host-derived heme to satisfy their nutritional iron requirement. However, heme is a toxic molecule capable of damaging the bacterial cell. Gram-positive pathogens within the phylum Firmicutes overcome heme toxicity by sensing heme through HssRS, a two-component system that regulates the heme detoxification transporter HrtAB. Here we show that heme sensing by HssRS and heme detoxification by HrtAB occur in the insect pathogen Bacillus thuringiensis We… CONTINUE READING
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