Heme requirement and intracellular trafficking in Trypanosoma cruzi epimastigotes.

@article{Lara2007HemeRA,
  title={Heme requirement and intracellular trafficking in Trypanosoma cruzi epimastigotes.},
  author={Fontanella Lara and Celso Sant'anna and Daniel Campos Lopes Lemos and Gustavo Augusto Travassos Laranja and Marsen Garcia Pinto Coelho and I Reis Salles and Antje Michel and Pedro L Oliveira and Narcisa L Cunha-E-Silva and Didier Salmon and Marcia Cristina Paes},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={355 1},
  pages={
          16-22
        }
}
Epimastigotes multiplies in the insect midgut by taking up nutrients present in the blood meal including heme bound to hemoglobin of red blood cell. During blood meal digestion by vector proteases in the posterior midgut, hemoglobin is clipped off into amino acids, peptides, and free heme. In this paper, we compared the heme and hemoglobin uptake kinetics and followed their intracellular trafficking. Addition of heme to culture medium increased epimastigote proliferation in a dose-dependent… CONTINUE READING
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