Heme regulates SOD2 transcription by activation and repression in Saccharomyces cerevisiae

Abstract

SOD2 encodes the Saccharomyces cerevisiae manganese superoxide dismutase (MnSOD), a mitochondrial matrix protein. Heme regulates SOD2 transcription during both fermentative and respiratory growth by three mechanisms. First, SOD2 transcription is activated 10-fold by growth on a non-fermentable carbon source via the heme activator protein (Hap) 2-3-4-5… (More)
DOI: 10.1007/s002940050207

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