Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.

@article{Tahara2004HemePR,
  title={Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.},
  author={Tsuyoshi Tahara and Jiying Sun and Katsuyuki Nakanishi and Masafumi Yamamoto and Hajime Mori and Takeshi Saito and Hiroyoshi Fujita and Kazuhiko Igarashi and Shigeru Taketani},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 7},
  pages={5480-7}
}
The transcription factor Bach1 heterodimerizes with small Maf proteins to repress Maf recognition element (MARE)-dependent gene expression. The repressor activity of Bach1 is inhibited by the direct binding of heme. To investigate the involvement of Bach1 in the heme-dependent regulation of the expression of the beta-globin gene, mouse erythroleukemia (MEL) cells were cultured with succinylacetone (SA), a specific inhibitor of heme biosynthesis, and the level of beta-globin mRNA was examined. A… CONTINUE READING

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