Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine.

@article{Liang2003HemeOT,
  title={Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine.},
  author={Di Liang and X Li and Geoff K Lighthall and John David Clark},
  journal={Neuroscience},
  year={2003},
  volume={121 4},
  pages={999-1005}
}
The heme oxygenase (HO) enzyme system has been shown to participate in nociceptive signaling in a number of different models of pain. In these experiments we investigated the role of the HO type 2 (HO-2) isozyme in tolerance to the analgesic effects of morphine, and the hyperalgesia and allodynia which are measurable upon cessation of administration. Wild type C57Bl/6 wild type mice or HO-2 null mutants in that background strain were treated with morphine for 5 days. The morphine administration… CONTINUE READING

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