Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis.

@article{Czaikoski2013HemeOI,
  title={Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis.},
  author={Paula Giselle Czaikoski and Daniele Carvalho Nascimento and Fabiane S{\^o}nego and Andressa de Freitas and Walter Miguel Turato and M. A. de Carvalho and Raquel Souza Santos and Gisele Pena de Oliveira and Cynthia dos Santos Samary and Cristiane Tef{\'e}-Silva and Jos{\'e} Carlos F Alves-Filho and S{\'e}rgio Henrique Ferreira and Marcos Ant{\^o}nio Rossi and Patricia R M Rocco and Fernando Spiller and Fernando Q Cunha},
  journal={Shock},
  year={2013},
  volume={39 4},
  pages={389-96}
}
A reduction of the neutrophil migration into the site of infection during cecal ligation and puncture-induced sepsis increases host mortality. Inhibition of heme oxygenase (HO) prevents this neutrophil paralysis and improves host survival in the cecal ligation and puncture model. Taking into account that almost 50% of all sepsis cases are a consequence of pneumonia, we designed the present study to determine the role of HO in an experimental model of pneumonia-induced sepsis. The objective of… CONTINUE READING

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